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Are drug-coated balloons ready for non-small-vessels? Insights from a four-year real-world analysis
Session:
Sessão de Posters 06 - Balões revestidos na ICP contemporânea
Speaker:
José Luís Ferraro
Congress:
CPC 2026
Topic:
H. Interventional Cardiology and Cardiovascular Surgery
Theme:
25. Interventional Cardiology
Subtheme:
25.2 Coronary Intervention
Session Type:
Posters Eletrónicos
FP Number:
---
Authors:
José Luís Ferraro; Inês Gomes Campos; Carla Almeida; Joel Ponte Monteiro; Rui Pontes Dos Santos; Rafaela Gonçalves Lopes; Inês Bastos Castro; Mauro Moreira; Ana Rodrigo Costa; Aurora Andrade
Abstract
<p style="text-align:justify"><span style="font-size:12px"><span style="font-family:Arial,Helvetica,sans-serif">Background: Drug-coated balloons (DCB) are increasingly used in percutaneous coronary interventions, particularly in small coronary vessels. We aimed to evaluate angiographic performance and clinical outcomes according to vessel size in a four-year single-centre DCB registry.</span></span></p> <p style="text-align:justify"><span style="font-size:12px"><span style="font-family:Arial,Helvetica,sans-serif">Methods: Consecutive patients treated with DCB between 2021–2025 were included. Lesions were classified as small-vessel (<3 mm) or non–small-vessel (≥3 mm) using DCB diameter. Outcomes included angiographic success (residual stenosis <30% with TIMI 3), recoil, bailout stenting, and clinically driven target lesion/vessel revascularisation (TLR/TVR). </span></span></p> <p style="text-align:justify"><span style="font-size:12px"><span style="font-family:Arial,Helvetica,sans-serif">Results: A total of 150 patients were included, 93 (62%) with small-vessel lesion and 57 (38%) non–small-vessel lesion. Baseline demographic characteristics were similar (mean age 67.25 ± 10.27 vs. 66.65 ± 10.35 years, p = 0.730), predominantly men (p=0.612). DM and history of previous ACS was significantly more prevalent in the non-small lesion group (<em>p</em>=0.014 and p<0.001). There were no significant differences for hypertension and dyslipidemia. Regarding clinical presentation at admission (STEMI, NSTEMI, unstable angina or CCS), there were no significant differences (p=0.271). Treated vessels (LAD, Cx and RCA) were comparable between groups, <em>p</em> = 0.561. Angiographic success was high and comparable (96.5% vs. 96.8%, p=0.925). Recoil patterns showed no significant differences across vessel sizes (p=0.277). Bailout stenting remained infrequent (5.4% vs. 7.1%, p=0.440). TLR occurred only in the small-vessel group (3.5%), with none in non-small-vessel group (p=0.069). TVR showed no meaningful difference (p=0.200). Periprocedural complications including MI, major bleeding and contrast-induced nephropathy were absent in both groups. There were no unplanned readmissions at 6 months. No cardiavascular deaths were recorded.</span></span></p> <p style="text-align:justify"><span style="font-size:12px"><span style="font-family:Arial,Helvetica,sans-serif">Conclusion: In this four-year real-world registry, DCB angioplasty achieved uniformly high angiographic success and an excellent safety profile in both small and non–small-vessel lesions. Although DCBs have historically been used predominantly in small vessels, our study demonstrates that they are equally safe and effective in larger-calibre vessels. These results support the reliability and consistency of DCB-based PCI across different vessel sizes.</span></span></p>
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