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A. Basics
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07. Syncope and Bradycardia
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Association of CA-125 with Congestion Markers in Acute Coronary Syndrome
Session:
Sessão de Posters 10 - Cuidados modernos na insuficiência cardíaca: congestão, metabolismo e resultados
Speaker:
David Campos
Congress:
CPC 2026
Topic:
E. Coronary Artery Disease, Acute Coronary Syndromes, Acute Cardiac Care
Theme:
13. Acute Coronary Syndromes
Subtheme:
13.6 Acute Coronary Syndromes - Clinical
Session Type:
Posters Eletrónicos
FP Number:
---
Authors:
David Campos; Marco Tomaz; Catarina Pohle; Patrícia Bernardes; Ivo Palmeiro; Ana Esteves; Sara Gonçalves; Filipe Seixo
Abstract
<p>Background: Tumour marker antigen carbohydrate 125 (CA-125) has emerged as a promising biomarker for assessing congestion in acute heart failure, complementing brain natriuretic peptide (BNP). While evidence supports CA-125’s role in acute heart failure following ST-elevation myocardial infarction (STEMI), its utility in evaluating congestion among patients with acute coronary syndrome (ACS) remains unclear.</p> <p>Purpose: To evaluate the association between CA-125 increase and congestion markers in patients presenting with ACS.</p> <p>Methods: We performed a retrospective analysis of consecutive ACS patients hospitalized from July to November 2025. Baseline characteristics and clinical presentation at admission were recorded. CA-125 levels at admission were compared with congestion indicators, including Killip-Kimbal class, diuretic use, and NT-proBNP levels.</p> <p>Results: A total of 52 patients were included (median age 67 years; 73% male), with 32 (61.5%) presenting with NSTEMI. 14 patients (27%) had a Killip-Kimbal class ≥2 during hospitalization, and 15 (29%) received diuretics. Mean CA-125 was 29.7 ± 58.1 UI/mL, and mean NT-proBNP was 3880 ± 5996 pg/mL. A statistically significant positive correlation was observed between CA-125 and NT-proBNP (Spearman’s rho = 0.295, p = 0.034). However, no significant associations were found between CA-125 and Killip-Kimbal class (p = 0.12) or diuretic use (p = 0.19).</p> <p>Conclusion: CA-125 levels correlate positively with NT-proBNP in ACS patients, supporting its potential as a congestion biomarker. No definitive relationship was established between CA-125 and clinical congestion markers such as Killip-Kimbal class or diuretic therapy. Studies with larger samples are warranted to further investigate these findings.<br /> </p>
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