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A Decade of Leadless Pacemaker Implantation: Technical Performance, Safety and Device Longevity.
Session:
Sessão de Posters 29 - Pacing sem elétrodos e inovação em dispositivos
Speaker:
Joana Certo Pereira
Congress:
CPC 2026
Topic:
C. Arrhythmias and Device Therapy
Theme:
09. Device Therapy
Subtheme:
09.1 Antibradycardia Pacing
Session Type:
Posters Eletrónicos
FP Number:
---
Authors:
Joana Certo Pereira
Abstract
<p><span style="font-size:11pt"><span style="font-family:Calibri,sans-serif"><strong>Background: </strong>Leadless pacemakers (L-PM) eliminate the need for transvenous leads and pacemaker pockets, reducing lead-related complications. After more than a decade of clinical use worldwide, real-world data on long-term performance and management of end-of-life devices remain limited. We report a 10-year single-center experience focusing on procedural practice evolution, long-term pacing parameters, safety and battery longevity.</span></span></p> <p><span style="font-size:11pt"><span style="font-family:Calibri,sans-serif"><strong>Methods: </strong>Single-center prospective registry including all consecutive patients undergoing ventricular L-PM implantation from May 2015 to November 2025. Clinical characteristics, procedural data, pacing parameters and estimated battery longevity were collected at implant and at latest follow-up (FUP).</span></span></p> <p><span style="font-size:11pt"><span style="font-family:Calibri,sans-serif"><strong>Results </strong>The cohort included 447 patients (mean age 80.0±9.4 years; 64% male). Successful implantation occurred in 445 patients (99.6%). Main pacing indications were high-grade AV block (64%) and atrial fibrillation with pauses (27%). Notably, 8% of implants were performed after extraction of an infected conventional system and 17% following transcatheter structural heart procedures.</span></span></p> <p><span style="font-size:11pt"><span style="font-family:Calibri,sans-serif">Procedural efficiency improved over the years, with global mean procedure and fluoroscopy times of 41.1±24.7 min and 4.4±3.8 min. Acute major complications were infrequent: pericardial effusion occurred in 0.9% (one tamponade), and 0.4% required conversion to a transvenous pacemaker (one due to acute L-PM dysfunction and the other due to a small RV cavity). Additionally, two lymphatic access-site complications were reported, one requiring surgical treatment. No device dislodgment occurred.</span></span></p> <p><span style="font-size:11pt"><span style="font-family:Calibri,sans-serif"><span style="color:black">During a mean FUP of 2.5 ± 2.3 years, pacing parameters remained stable (threshold: 0.64 to 0.60V; R-wave amplitude: 12.3 to 12.5mV). Mean ventricular pacing was 59±39% and estimated battery longevity was >8 years in 84%. Among those with >5-year of FUP (N=60; mean FUP 6.7±2.4 years), 80% maintained >5 years of predicted longevity. Three upgrades to CRT or LBBAP occurred due to pacing-induced LV dysfunction. One true end-of-life event occurred 6 years post-implant (100% VP, high thresholds), successfully managed with a second L-PM. There were 119 deaths (27%), none device-related.</span></span></span></p> <p><span style="font-size:11pt"><span style="font-family:Calibri,sans-serif"><strong>Conclusion: </strong>Over 10 years of experience, L-PM implantation proved to be a robust and safe pacing modality in routine practice, maintaining stable electrical performance and excellent battery durability, with only one device reaching end-of-life. Ongoing <span style="color:black">FUP</span> will clarify long-term replacement strategies and lifetime device management in this growing population.</span></span></p>
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