Login
Search
Search
0 Dates
2026
2025
2024
2023
2022
2021
2020
2019
2018
0 Events
CPC 2018
CPC 2019
Curso de Atualização em Medicina Cardiovascular 2019
Reunião Anual Conjunta dos Grupos de Estudo de Cirurgia Cardíaca, Doenças Valvulares e Ecocardiografia da SPC
CPC 2020
CPC 2021
CPC 2022
CPC 2023
CPC 2024
CPC 2025
CPC 2026
0 Topics
A. Basics
B. Imaging
C. Arrhythmias and Device Therapy
D. Heart Failure
E. Coronary Artery Disease, Acute Coronary Syndromes, Acute Cardiac Care
F. Valvular, Myocardial, Pericardial, Pulmonary, Congenital Heart Disease
G. Aortic Disease, Peripheral Vascular Disease, Stroke
H. Interventional Cardiology and Cardiovascular Surgery
I. Hypertension
J. Preventive Cardiology
K. Cardiovascular Disease In Special Populations
L. Cardiovascular Pharmacology
M. Cardiovascular Nursing
N. E-Cardiology / Digital Health, Public Health, Health Economics, Research Methodology
O. Basic Science
P. Other
0 Themes
01. History of Cardiology
02. Clinical Skills
03. Imaging
04. Arrhythmias, General
05. Atrial Fibrillation
06. Supraventricular Tachycardia (non-AF)
07. Syncope and Bradycardia
08. Ventricular Arrhythmias and Sudden Cardiac Death (SCD)
09. Device Therapy
10. Chronic Heart Failure
11. Acute Heart Failure
12. Coronary Artery Disease (Chronic)
13. Acute Coronary Syndromes
14. Acute Cardiac Care
15. Valvular Heart Disease
16. Infective Endocarditis
17. Myocardial Disease
18. Pericardial Disease
19. Tumors of the Heart
20. Congenital Heart Disease and Pediatric Cardiology
21. Pulmonary Circulation, Pulmonary Embolism, Right Heart Failure
22. Aortic Disease
23. Peripheral Vascular and Cerebrovascular Disease
24. Stroke
25. Interventional Cardiology
26. Cardiovascular Surgery
27. Hypertension
28. Risk Factors and Prevention
29. Rehabilitation and Sports Cardiology
30. Cardiovascular Disease in Special Populations
31. Pharmacology and Pharmacotherapy
32. Cardiovascular Nursing
33. e-Cardiology / Digital Health
34. Public Health and Health Economics
35. Research Methodology
36. Basic Science
37. Miscellanea
0 Resources
Abstract
Slides
Vídeo
Report
CLEAR FILTERS
Left atrium strain in rheumatoid arthritis
Session:
Sessão de Posters 52 - Função auricular, interação ventricular e fenotipagem miocárdica
Speaker:
José Rodrigues Gomes
Congress:
CPC 2026
Topic:
B. Imaging
Theme:
03. Imaging
Subtheme:
03.1 Echocardiography
Session Type:
Posters Eletrónicos
FP Number:
---
Authors:
David Sá Couto; José Rodrigues Gomes; André Alexandre; Mariana Brandão; Sofia Cabral; Tomás Fonseca; Rita Quelhas Costa; António Marinho; Betânia Ferreira; João Pedro Ferreira; Patrícia Rodrigues
Abstract
<p><strong>Background:</strong><br /> Rheumatoid arthritis (RA) increases the risk of heart failure (HF) through mechanisms that extend beyond traditional cardiovascular risk factors. Left atrial (LA) strain (LAs) is emerging as a sensitive marker of subclinical myocardial dysfunction and elevated filling pressures. Understanding its role could improve early detection of cardiac involvement in this population. This study investigated the associations of LAs with clinical, laboratory, and echocardiographic parameters, as well as long-term outcomes, in RA patients without known cardiac disease.</p> <p><strong>Methods:</strong><br /> This prospective observational study included RA patients enrolled in a tertiary-care cohort. All participants underwent comprehensive echocardiographic assessment with LAs analysis and were stratified into two groups based on the median LA reservoir strain (LARs). The primary endpoint was a composite of myocardial infarction, stroke, atrial fibrillation, HF hospitalization, or cardiovascular death. Secondary endpoints included each component individually and all-cause mortality. Median [P25–75] follow-up time was 6.2 [5.6–6.6] years. Additional exploratory analyses evaluated correlations between LAs and disease activity, biomarkers, and ventricular strain parameters.</p> <p><strong>Results:</strong><br /> Of 364 enrolled patients, 260 had analysable LAs data and were included. Median LARs was 37.4%; 131 (50.4%) exhibited LARs ≤ median and 129 (49.6%) > median. Patients with lower LARs were older, walked shorter distances on the 6-minute walk test, and demonstrated higher hs-troponin T and NT-proBNP levels, higher E/e’, and lower LV global longitudinal strain. Despite these unfavorable phenotypic differences, the incidence of the primary endpoint did not differ significantly between groups (15.5 vs. 10.3 events/1000 patient-years; HR 0.64 [0.26–1.57]; p = 0.33). A trend toward higher all-cause mortality in the lower LARs group (12.5 vs. 3.75 events/1000 patient-years; HR 0.29 [0.078–1.04]; p = 0.06) was observed, although not statistically significant. Notably, only a minority fulfilled criteria for abnormal LA strain based on published reference values.</p> <p><strong>Conclusion:</strong><br /> In RA patients without overt cardiac disease, LARs ≤ 37.4% was associated with reduced functional capacity, subtle but consistent alterations in cardiac structure and function, and higher levels of cardiovascular disease biomarkers. Although LARs was not independently associated with adverse cardiovascular outcomes, its strong relationship with indices of subclinical myocardial dysfunction suggests that it may help refine cardiovascular risk stratification in RA. Larger, adequately powered prospective studies are warranted to determine whether LAs can serve as an early screening tool for cardiac involvement in this high-risk population.</p>
Slides
Our mission: To reduce the burden of cardiovascular disease
Visit our site