Login
Search
Search
0 Dates
2026
2025
2024
2023
2022
2021
2020
2019
2018
0 Events
CPC 2018
CPC 2019
Curso de Atualização em Medicina Cardiovascular 2019
Reunião Anual Conjunta dos Grupos de Estudo de Cirurgia Cardíaca, Doenças Valvulares e Ecocardiografia da SPC
CPC 2020
CPC 2021
CPC 2022
CPC 2023
CPC 2024
CPC 2025
CPC 2026
0 Topics
A. Basics
B. Imaging
C. Arrhythmias and Device Therapy
D. Heart Failure
E. Coronary Artery Disease, Acute Coronary Syndromes, Acute Cardiac Care
F. Valvular, Myocardial, Pericardial, Pulmonary, Congenital Heart Disease
G. Aortic Disease, Peripheral Vascular Disease, Stroke
H. Interventional Cardiology and Cardiovascular Surgery
I. Hypertension
J. Preventive Cardiology
K. Cardiovascular Disease In Special Populations
L. Cardiovascular Pharmacology
M. Cardiovascular Nursing
N. E-Cardiology / Digital Health, Public Health, Health Economics, Research Methodology
O. Basic Science
P. Other
0 Themes
01. History of Cardiology
02. Clinical Skills
03. Imaging
04. Arrhythmias, General
05. Atrial Fibrillation
06. Supraventricular Tachycardia (non-AF)
07. Syncope and Bradycardia
08. Ventricular Arrhythmias and Sudden Cardiac Death (SCD)
09. Device Therapy
10. Chronic Heart Failure
11. Acute Heart Failure
12. Coronary Artery Disease (Chronic)
13. Acute Coronary Syndromes
14. Acute Cardiac Care
15. Valvular Heart Disease
16. Infective Endocarditis
17. Myocardial Disease
18. Pericardial Disease
19. Tumors of the Heart
20. Congenital Heart Disease and Pediatric Cardiology
21. Pulmonary Circulation, Pulmonary Embolism, Right Heart Failure
22. Aortic Disease
23. Peripheral Vascular and Cerebrovascular Disease
24. Stroke
25. Interventional Cardiology
26. Cardiovascular Surgery
27. Hypertension
28. Risk Factors and Prevention
29. Rehabilitation and Sports Cardiology
30. Cardiovascular Disease in Special Populations
31. Pharmacology and Pharmacotherapy
32. Cardiovascular Nursing
33. e-Cardiology / Digital Health
34. Public Health and Health Economics
35. Research Methodology
36. Basic Science
37. Miscellanea
0 Resources
Abstract
Slides
Vídeo
Report
CLEAR FILTERS
Right ventricular to pulmonary artery coupling: the diagnostic value in distinguishing hypertrophic cardiomyopathy and wild-type transthyretin cardiac amyloidosis
Session:
Sessão de Posters 52 - Função auricular, interação ventricular e fenotipagem miocárdica
Speaker:
Luísa Pinheiro
Congress:
CPC 2026
Topic:
B. Imaging
Theme:
03. Imaging
Subtheme:
03.1 Echocardiography
Session Type:
Posters Eletrónicos
FP Number:
---
Authors:
Luísa Pinheiro; Emídio Mata; Tamara Pereira; Margarida Castro; Bárbara Lage Garcia; Daniela Ferreira; Mário Lourenço; Filipa Cordeiro; Marina Fernandes; Olga Azevedo; António Lourenço
Abstract
<p style="text-align:justify"><span style="font-family:Arial,Helvetica,sans-serif"><span style="font-size:12pt"><strong>Background: </strong>Right ventricular (RV) to pulmonary artery (PA) coupling reflects how effectively the RV adapts to the afterload imposed by the pulmonary circulation. Emerging evidence suggests that disruption of this relationship—RV-PA uncoupling—may occur differently across cardiomyopathies. Hypertrophic cardiomyopathy (HCM) typically features preserved RV function until advanced stages, whereas wild-type transthyretin cardiac amyloidosis (ATTR-CM) is marked by earlier impairment of RV mechanics. </span></span></p> <p style="text-align:justify"><span style="font-family:Arial,Helvetica,sans-serif"><span style="font-size:12pt"><strong>Aim:</strong> To determine whether RV–PA coupling indices – TAPSE/PASP (Tricuspid Annular Plane Systolic Excursion/Pulmonary Artery Systolic Pressure), FAC/PASP (Fractional Area Change), and RV-FWS/PASP (Right Ventricular Free Wall Strain) <span style="color:black">– have diagnostic utility in differentiating HCM from ATTR-CM. </span></span></span></p> <p style="text-align:justify"><span style="font-family:Arial,Helvetica,sans-serif"><span style="font-size:12pt"><strong><span style="color:black">Methods:</span></strong><span style="color:black"> This retrospective study included HCM (n=30) and ATTR-CM (n=30) patients. Two blinded observers assessed RV structure and function using echocardiography and 2D-STE. Receiver operating characteristic (ROC) analysis assessed the diagnostic performance of the </span>coupling indices<span style="color:black">, with DeLong’s test used for curve comparison. </span></span></span></p> <p style="text-align:justify"><span style="font-family:Arial,Helvetica,sans-serif"><span style="font-size:12pt"><strong><span style="color:black">Results:</span></strong><span style="color:black"> ATTR-CM patients were older than HCM patients (83.4±4.8 vs 59.8±13.6 years, p<0.001), had higher NT-proBNP levels (11001±15080 vs 1117±1103pg/ml, p<0.001) and similar septal wall thickness (18.9±2.7 vs 18.7±2.3, p=0.769). ATTR-CM patients also presented lower TAPSE/PASP ratio (0.428±0.199 vs 0.754±0.219, p<0.001), FAC/PASP ratio (0.855±0.358 vs 1.420±0.367, p<0.001) and RV-FWS/PASP ratio (0.246±0.120 vs 0.434±0.143, p<0.001). In ROC curve analysis, TAPSE/PASP ratio had an area under the curve (AUC) of 0.865 [0.752–0.939] (p<0.0001) with an associated cutoff of ≤0.537 for identifying ATTR-CM (sensitivity: 70%; specificity: 86.7%). FAC/PASP ratio showed an AUC of 0.857 [0.742–0.934] (p<0.0001) with an associated cutoff of ≤1.03 for identifying ATTR-CM (sensitivity: 73.33%; specificity: 83.33%). The RV-FWS/PASP ratio had an AUC of 0.849 [0.739-0.929] (p<0.0001) with an associated cutoff of ≤0.275 for identifying ATTR-CM (sensitivity: 60%; specificity: 93.33%). Pairwise comparisons showed no significant difference between the three ratios in distinguishing ATTR-CM from HCM. When compared to the RV function parameters not normalized to load, the AUCs for TAPSE and FAC were numerically lower than those of the load-normalized parameters (AUC of 0.740 for TAPSE, AUC of 0.709 for FAC and AUC of 0.894 for RV-FWS).</span></span></span></p> <p style="text-align:justify"><span style="font-family:Arial,Helvetica,sans-serif"><span style="font-size:12pt"><strong><span style="color:black">Conclusion:</span></strong><span style="color:black"> Overall, RV-PA coupling indices were all significantly lower in ATTR-CM compared with HCM, demonstrated good diagnostic accuracy for distinguishing the two conditions, and two of them outperformed the parameters not normalized to load. All three measures showed consistent discriminatory value, supporting RV–PA coupling assessment as a useful adjunct in differentiating ATTR-CM from HCM.</span></span></span></p>
Slides
Our mission: To reduce the burden of cardiovascular disease
Visit our site