Login
Search
Search
0 Dates
2026
2025
2024
2023
2022
2021
2020
2019
2018
0 Events
CPC 2018
CPC 2019
Curso de Atualização em Medicina Cardiovascular 2019
Reunião Anual Conjunta dos Grupos de Estudo de Cirurgia Cardíaca, Doenças Valvulares e Ecocardiografia da SPC
CPC 2020
CPC 2021
CPC 2022
CPC 2023
CPC 2024
CPC 2025
CPC 2026
0 Topics
A. Basics
B. Imaging
C. Arrhythmias and Device Therapy
D. Heart Failure
E. Coronary Artery Disease, Acute Coronary Syndromes, Acute Cardiac Care
F. Valvular, Myocardial, Pericardial, Pulmonary, Congenital Heart Disease
G. Aortic Disease, Peripheral Vascular Disease, Stroke
H. Interventional Cardiology and Cardiovascular Surgery
I. Hypertension
J. Preventive Cardiology
K. Cardiovascular Disease In Special Populations
L. Cardiovascular Pharmacology
M. Cardiovascular Nursing
N. E-Cardiology / Digital Health, Public Health, Health Economics, Research Methodology
O. Basic Science
P. Other
0 Themes
01. History of Cardiology
02. Clinical Skills
03. Imaging
04. Arrhythmias, General
05. Atrial Fibrillation
06. Supraventricular Tachycardia (non-AF)
07. Syncope and Bradycardia
08. Ventricular Arrhythmias and Sudden Cardiac Death (SCD)
09. Device Therapy
10. Chronic Heart Failure
11. Acute Heart Failure
12. Coronary Artery Disease (Chronic)
13. Acute Coronary Syndromes
14. Acute Cardiac Care
15. Valvular Heart Disease
16. Infective Endocarditis
17. Myocardial Disease
18. Pericardial Disease
19. Tumors of the Heart
20. Congenital Heart Disease and Pediatric Cardiology
21. Pulmonary Circulation, Pulmonary Embolism, Right Heart Failure
22. Aortic Disease
23. Peripheral Vascular and Cerebrovascular Disease
24. Stroke
25. Interventional Cardiology
26. Cardiovascular Surgery
27. Hypertension
28. Risk Factors and Prevention
29. Rehabilitation and Sports Cardiology
30. Cardiovascular Disease in Special Populations
31. Pharmacology and Pharmacotherapy
32. Cardiovascular Nursing
33. e-Cardiology / Digital Health
34. Public Health and Health Economics
35. Research Methodology
36. Basic Science
37. Miscellanea
0 Resources
Abstract
Slides
Vídeo
Report
CLEAR FILTERS
Size does matter: a simple swine model of chronic pulmonary hypertension
Session:
Sessão de Comunicações Orais 02 – Perspectivas translacionais na Insuficiência Cardíaca: dos modelos experimentais ao prognóstico clínico
Speaker:
Liliana Isabel Moreira Costa
Congress:
CPC 2026
Topic:
D. Heart Failure
Theme:
21. Pulmonary Circulation, Pulmonary Embolism, Right Heart Failure
Subtheme:
21.1 Pulmonary Circulation, Pulmonary Embolism, Right Heart Failure – Pathophysiology and Mechanisms
Session Type:
Comunicações Orais
FP Number:
---
Authors:
Liliana Moreira-Costa; André Leite-Moreira; Rui Adão; Isabel Miranda; Rui Cerqueira; Frédéric Perros; Adelino F. Leite-Moreira; André P. Lourenço; Pedro Mendes-Ferreira
Abstract
<p style="text-align:justify"><span style="font-size:11pt"><span style="font-family:Aptos,sans-serif"><strong><span style="font-size:12.0pt"><span style="font-family:"Arial",sans-serif">Introduction: </span></span></strong><span style="font-size:12.0pt"><span style="font-family:"Arial",sans-serif">There is a need for large animal models of pulmonary hypertension (PH) that allow application of new therapies in a translational setting.</span></span></span></span></p> <p style="text-align:justify"><span style="font-size:11pt"><span style="font-family:Aptos,sans-serif"><strong><span style="font-size:12.0pt"><span style="font-family:"Arial",sans-serif">Aims and objectives: </span></span></strong><span style="font-size:12.0pt"><span style="font-family:"Arial",sans-serif">To develop a simple large animal model of PH with right ventricular (RV) failure, mimicking chronic thromboembolic PH (CTEPH). Previous attempts have used short suture segments, microspheres and pharmacological interventions.</span></span></span></span></p> <p style="text-align:justify"><span style="font-size:11pt"><span style="font-family:Aptos,sans-serif"><strong><span style="font-size:12.0pt"><span style="font-family:"Arial",sans-serif">Methods: </span></span></strong><span style="font-size:12.0pt"><span style="font-family:"Arial",sans-serif">2-month old pigs were used. Right heart catheterization (RHC) was performed, and a sheath was advanced into the left or right PA and a pressure transducer was placed at its tip. Long silk sutures were injected into the selected PA, while continuously recording pressures. Embolization was stopped when mean PAP≥40 mmHg, or occlusion of the selected branch. The procedure was repeated for 3 weeks, with a 4 weeks follow-up. Echocardiographic and hemodynamic analysis was performed and samples were collected.</span></span></span></span></p> <p style="text-align:justify"><span style="font-size:11pt"><span style="font-family:Aptos,sans-serif"><strong><span style="font-size:12.0pt"><span style="font-family:"Arial",sans-serif">Results: </span></span></strong><span style="font-size:12.0pt"><span style="font-family:"Arial",sans-serif">Embolization led to an increase in mPA pressure and reduction in cardiac output. RHC showed severe PH development (mPAP = 49 +/- 5 mmHg). A significant portion of both right and left lower lobes were obstructed. Significant RV hypertrophy and failure (lower TAPSE and EF) were observed. Adverse remodelling markers (MYH7/MYH6, NPPB and TNFA) were upregulated, while ATP2A2 was down-regulated. Isolated skinned RV cardiomyocyte analysis showed significantly increased passive stiffness. Vascular remodelling was observed in distal arteries of the right upper lung lobe subjected to high flow/high shear stress.</span></span></span></span></p> <p><span style="font-size:11pt"><span style="font-family:Aptos,sans-serif"><strong><span style="font-size:12.0pt"><span style="font-family:"Arial",sans-serif">Conclusions: </span></span></strong><span style="font-size:12.0pt"><span style="font-family:"Arial",sans-serif">We created a model of chronic PH by injecting long sutures into the pulmonary circulation, without the need for additional hits, which may be valuable for preclinical research. </span></span></span></span></p>
Our mission: To reduce the burden of cardiovascular disease
Visit our site