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CLEAR FILTERS
The high HDL controversy continues: The prognosis for women with a high HDL profile is seriously unfavourable
Session:
SESSÃO DE POSTERS 36 - TUDO SOBRE LÍPIDOS
Speaker:
Francisco Sousa
Congress:
CPC 2025
Topic:
K. Cardiovascular Disease In Special Populations
Theme:
30. Cardiovascular Disease in Special Populations
Subtheme:
30.14 Cardiovascular Disease in Special Populations - Other
Session Type:
Cartazes
FP Number:
---
Authors:
Francisco Sousa; Maria Isabel Mendonça; Débora Sá; Gonçalo Abreu; Matilde Ferreira; Eva Henriques; Sónia Freitas; Mariana Rodrigues; Sofia Borges; António Drumond; Ana Célia Sousa; Roberto Palma Dos Reis
Abstract
<p style="text-align:justify"><span style="font-size:12pt"><span style="font-family:Calibri,sans-serif"><span style="color:#000000"><strong>Background:</strong></span></span></span><span style="font-size:12pt"><span style="font-family:Calibri,sans-serif"><span style="color:#000000"> Elevated HDL-c has been associated with increased all-cause mortality in conditions like cancer or liver disease. The traditional "more HDL is better" paradigm is no longer universally accepted. Understanding prognosis is crucial in evaluating cardiovascular and overall risk, especially in women.</span></span></span></p> <p><span style="font-size:12pt"><span style="font-family:Calibri,sans-serif"><span style="color:#000000"><strong>Aim:</strong></span></span></span><span style="font-size:12pt"><span style="font-family:Calibri,sans-serif"><span style="color:#000000"> To investigate the association between HDL-c levels and all causes of events and mortality in a Southern European Population. </span></span></span></p> <p><span style="font-size:12pt"><span style="font-family:Calibri,sans-serif"><span style="color:#000000"><strong>Methods: </strong></span></span></span><span style="font-size:12pt"><span style="font-family:Calibri,sans-serif"><span style="color:#000000">1421 normal individuals from a Southern European population (aged 52.2±8.3 years, 73.6% male) were followed during an extended follow-up (mean of 7.3±5.2 years). Demographic data, smoking status, alcohol intake, physical activity and clinical risk factors were collected from questionnaires at baseline in 2000. Continuous data were expressed as the mean±SD and compared using t Student test. Categorical variables were described by percentages and compared using the Chi-square test. The population was stratified into six groups based on HDL-c levels in mg/dl (<40, 40 to 49, 50 to 59, 60 to 69, 70 to 79, and ≥80). To investigate the association between HDL-c levels and events, we subdivided each category level into three subgroups (overall population, male and female). In an adjusted multivariate model, Cox regression tested the association between HDL-c levels and all-cause events and mortality (vascular and non-cardiovascular) adjusted for potential confounders. </span></span></span></p> <p style="text-align:justify"><span style="font-size:12pt"><span style="font-family:Calibri,sans-serif"><span style="color:#000000"><strong>Results: </strong></span></span></span><span style="font-size:12pt"><span style="font-family:Calibri,sans-serif"><span style="color:#000000">At the end of follow-up, 156 total events (vascular and nonvascular) were identified (event rate, 15.3 per 1,000 person-years). In the lower category of HDL, the general population subgroup and men were significantly associated with an increase in total events compared to the reference group. However, in the highest HDL profile (≥80mg/dl), the women have a much higher risk of events (5 times more risk than the reference and, approximately, 2.5 times above men).</span></span></span></p> <p style="text-align:justify"><span style="font-size:12pt"><span style="font-family:Calibri,sans-serif"><span style="color:#000000"><strong>Conclusion: </strong></span></span></span><span style="font-size:12pt"><span style="font-family:Calibri,sans-serif"><span style="color:#000000">Our findings highlight the importance of appropriate HDL-C levels in reducing the risk of events and death and challenge the conventional notion that higher HDL-c levels are better. More studies are necessary to clarify whether the associations observed in our study are causal and to elucidate the potential mechanisms.</span></span></span></p>
Slides
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