SPC365

Fibrinogen is a predictor of cerebrovascular disease risk in a Portuguese population

Session: SESSÃO DE POSTERS 36 - TUDO SOBRE LÍPIDOS
Speaker: Cátia A. Martins

Congress: CPC 2025
Topic: K. Cardiovascular Disease In Special Populations
Theme: 30. Cardiovascular Disease in Special Populations
Subtheme: 30.1 Cardiovascular Disease in Primary Care
Session Type: Cartazes
FP Number: ---
Authors: Cátia A. Martins; Ana Célia Sousa; Patrícia Nunes; João Gouveia; Sofia Almada; Mónica Jardim; Sofia Borges; Maria João Oliveira; Mariana Rodrigues; Eva Henriques; Maria Isabel Mendonça; Roberto Palma Dos Reis

<p style="text-align:justify"><span style="font-size:11pt"><span style="font-family:Calibri,&quot;sans-serif&quot;"><strong>Introduction: </strong></span></span></p>

<p style="text-align:justify"><span style="font-size:11pt"><span style="font-family:Calibri,&quot;sans-serif&quot;">Several studies report that markers of systemic inflammation, such as fibrinogen, are involved in atherosclerosis and endothelial dysfunction and associated with cardiovascular disease. However, the role of these inflammatory markers in the pathophysiology of cerebrovascular disease (CVD) is still incompletely understood.</span></span></p>

<p style="text-align:justify">&nbsp;</p>

<p style="text-align:justify"><span style="font-size:11pt"><span style="font-family:Calibri,&quot;sans-serif&quot;"><strong>Objective:</strong></span></span></p>

<p style="text-align:justify"><span style="font-size:11pt"><span style="font-family:Calibri,&quot;sans-serif&quot;">With the present work, we intend to evaluate whether a marker of inflammation, fibrinogen is a predictor of cerebrovascular disease.</span></span></p>

<p style="text-align:justify">&nbsp;</p>

<p style="text-align:justify"><span style="font-size:11pt"><span style="font-family:Calibri,&quot;sans-serif&quot;"><strong>Methods:</strong> </span></span></p>

<p style="text-align:justify"><span style="font-size:11pt"><span style="font-family:Calibri,&quot;sans-serif&quot;">A study with 1390 individuals (74% male, mean age of 52.2&plusmn;8.3 years), without diagnosed cardiovascular or cerebrovascular disease at study entry were followed during 7.2&plusmn;5.2 years. Demographic and biochemical factors (e.g., fibrinogen) were evaluated, as well as CVD risk factors (diabetes, hypertension, dyslipidemia, obesity, smoking and sedentary lifestyle). </span></span></p>

<p style="text-align:justify"><span style="font-size:11pt"><span style="font-family:Calibri,&quot;sans-serif&quot;">We evaluated the individuals who, during the follow-up period, had ischemic CVD namely stroke or transient ischemic attack (TIA). A case-control study was performed comparing the cases group with stroke/TIA (n=33) with the normal control group (n=1357), in relation to serum fibrinogen. A ROC curve was performed and a cut-off point was calculated for fibrinogen in relation of having a stroke/TIA. Subsequently, a Cox regression analysis was performed with fibrinogen, adjusted for other traditional CVD risk factors (diabetes, hypertension, dyslipidemia, obesity, smoking, sedentary lifestyle). Finally, Kaplan Meier estimated the events-free survival. </span></span></p>

<p style="text-align:justify">&nbsp;</p>

<p style="text-align:justify"><span style="font-size:11pt"><span style="font-family:Calibri,&quot;sans-serif&quot;"><strong>Results: </strong></span></span></p>

<p style="text-align:justify"><span style="font-size:11pt"><span style="font-family:Calibri,&quot;sans-serif&quot;">Fibrinogen was higher in the stroke/TIA group than in the control group, with statistical significance (p=0.035). Cut-off point for fibrinogen risk was 369 mg/dL. After Cox analysis adjusted for traditional risk factors, fibrinogen remained in the equation, as well as smoking, being both significantly and independently associated with stroke/TIA (HR=2.513, 95%CI 1.164-5.428; p=0.019 and HR=3.039, 95%CI 1.533-6.026; p=0.001, respectively). Kaplan-Meier curves demonstrated that, during the follow-up period, individuals with higher fibrinogen are more likely to have a stroke/TIA.</span></span></p>

<p style="text-align:justify">&nbsp;</p>

<p style="text-align:justify"><span style="font-size:11pt"><span style="font-family:Calibri,&quot;sans-serif&quot;"><strong>Conclusions:</strong> </span></span></p>

<p style="text-align:justify"><span style="font-size:11pt"><span style="font-family:Calibri,&quot;sans-serif&quot;">According to the results obtained, it is noteworthy that the serum values of the inflammatory biomarkers such as fibrinogen are predictors of stroke/TIA risk. </span></span></p>

<p style="text-align:justify"><span style="font-size:11pt"><span style="font-family:Calibri,&quot;sans-serif&quot;">Given the importance of these markers in the involvement of atherosclerosis, endothelial dysfunction and their knowledge, it will help us in the future to find new therapeutic approaches.</span></span></p>