Login
Search
Search
0 Dates
2025
2024
2023
2022
2021
2020
2019
2018
0 Events
CPC 2018
CPC 2019
Curso de Atualização em Medicina Cardiovascular 2019
Reunião Anual Conjunta dos Grupos de Estudo de Cirurgia Cardíaca, Doenças Valvulares e Ecocardiografia da SPC
CPC 2020
CPC 2021
CPC 2022
CPC 2023
CPC 2024
CPC 2025
0 Topics
A. Basics
B. Imaging
C. Arrhythmias and Device Therapy
D. Heart Failure
E. Coronary Artery Disease, Acute Coronary Syndromes, Acute Cardiac Care
F. Valvular, Myocardial, Pericardial, Pulmonary, Congenital Heart Disease
G. Aortic Disease, Peripheral Vascular Disease, Stroke
H. Interventional Cardiology and Cardiovascular Surgery
I. Hypertension
J. Preventive Cardiology
K. Cardiovascular Disease In Special Populations
L. Cardiovascular Pharmacology
M. Cardiovascular Nursing
N. E-Cardiology / Digital Health, Public Health, Health Economics, Research Methodology
O. Basic Science
P. Other
0 Themes
01. History of Cardiology
02. Clinical Skills
03. Imaging
04. Arrhythmias, General
05. Atrial Fibrillation
06. Supraventricular Tachycardia (non-AF)
07. Syncope and Bradycardia
08. Ventricular Arrhythmias and Sudden Cardiac Death (SCD)
09. Device Therapy
10. Chronic Heart Failure
11. Acute Heart Failure
12. Coronary Artery Disease (Chronic)
13. Acute Coronary Syndromes
14. Acute Cardiac Care
15. Valvular Heart Disease
16. Infective Endocarditis
17. Myocardial Disease
18. Pericardial Disease
19. Tumors of the Heart
20. Congenital Heart Disease and Pediatric Cardiology
21. Pulmonary Circulation, Pulmonary Embolism, Right Heart Failure
22. Aortic Disease
23. Peripheral Vascular and Cerebrovascular Disease
24. Stroke
25. Interventional Cardiology
26. Cardiovascular Surgery
27. Hypertension
28. Risk Factors and Prevention
29. Rehabilitation and Sports Cardiology
30. Cardiovascular Disease in Special Populations
31. Pharmacology and Pharmacotherapy
32. Cardiovascular Nursing
33. e-Cardiology / Digital Health
34. Public Health and Health Economics
35. Research Methodology
36. Basic Science
37. Miscellanea
0 Resources
Abstract
Slides
Vídeo
Report
CLEAR FILTERS
Evaluating Superresponse in CRT: A clinical edge or just a remodeling effect?
Session:
SESSÃO DE POSTERS 52 - INSUFICIÊNCIA CARDÍACA, RESSINCRONIZAÇÃO E IMAGEM
Speaker:
Sofia Andraz
Congress:
CPC 2025
Topic:
---
Theme:
---
Subtheme:
---
Session Type:
Cartazes
FP Number:
---
Authors:
Sofia Andraz; Joana Massa Pereira; Lucas Hamann; Miguel Espírito Santo; Joana Guerreiro Pereira; Hugo Costa; Pedro de Azevedo; Jorge Mimoso
Abstract
<p style="text-align:justify"><span style="font-size:11pt"><span style="font-family:"Times New Roman",serif"><strong>Introduction</strong>: Cardiac resynchronization therapy (CRT) is a key treatment in modern heart failure (HF) management, as it significantly reduces morbidity and mortality in patients. Among CRT responders, a subset of patients, known as superresponders, demonstrate exceptional improvements cardiac remodeling. However, the prognostic benefit of superresponders compared to regular responders remains a subject of ongoing debate.</span></span></p> <p style="text-align:justify"><span style="font-size:11pt"><span style="font-family:"Times New Roman",serif"><strong>Objective</strong>: To determine the impact of superresponse on outcome.</span></span></p> <p style="text-align:justify"><span style="font-size:11pt"><span style="font-family:"Times New Roman",serif"><strong>Methods</strong>: This single-center retrospective analysis included 95 patients who underwent CRT implantation between January 2020 and December 2023, with a mean follow-up of 35 months. Patients were grouped in a superresponder group and a non-superresponder group. CRT superresponse criteria were defined as: increase in LVEF of, at least, 10% or a decrease in the diastolic or systolic volume of, at least, 20% and 30%, respectively. Data were collected on demographic characteristics, presence of left branch block in the initial electrocardiogram, the need for ventricular pacing, non-ischemic etiology, HF medical therapy and cardiac chambers volumes pre and post-implantation. We analysed the primary outcome as a composite outcome of death, HF admissions, myocardial infarction (MI), stroke. The secondary outcomes are death, HF admissions, MI and stroke.</span></span></p> <p style="text-align:justify"><span style="font-size:11pt"><span style="font-family:"Times New Roman",serif"><strong>Results</strong>: The final cohort consisted of 61 patients, with 37 patients (60.7%) categorized as non-superresponders (N-S-RESP) and 24 patients (39.3%) as superresponders (S-RESP). There were no significant differences in gender, age, hypertension, diabetes mellitus, dyslipidemia, smoking, alcohol use and need for ventricular pacing. Notably, obesity (29.7% vs 20.8%, p = 0.017) was significantly more common in non-superresponders. Non-ischemic heart disease was more frequent in the superresponders group (75% vs. 41.9%, p=0.014). There was a significant improvement in LVEF in both groups, which was higher in superresponders (LVEF pre: 29.2% vs LVEF post: 50.7%, p = 0.001). In contrast, non-superresponders exhibited a smaller, but also significant, change in LVEF (pre: 32.4% vs post: 36.6%, p = 0.044). Neither the primary outcome nor the secondary outcomes showed significant differences between groups.</span></span></p> <p style="text-align:justify"><span style="font-size:11pt"><span style="font-family:"Times New Roman",serif"><strong>Conclusions: </strong>While CRT superresponders have an enhanced cardiac remodeling, this did not translate into a significant difference in clinical outcomes such as death, HF admissions, MI or stroke. These findings support the role of CRT in preventing disease progression beyond improving LVEF, contributing to a partial or complete remission of the disease.</span></span></p>
Slides
Our mission: To reduce the burden of cardiovascular disease
Visit our site