Login
Search
Search
0 Dates
2025
2024
2023
2022
2021
2020
2019
2018
0 Events
CPC 2018
CPC 2019
Curso de Atualização em Medicina Cardiovascular 2019
Reunião Anual Conjunta dos Grupos de Estudo de Cirurgia Cardíaca, Doenças Valvulares e Ecocardiografia da SPC
CPC 2020
CPC 2021
CPC 2022
CPC 2023
CPC 2024
CPC 2025
0 Topics
A. Basics
B. Imaging
C. Arrhythmias and Device Therapy
D. Heart Failure
E. Coronary Artery Disease, Acute Coronary Syndromes, Acute Cardiac Care
F. Valvular, Myocardial, Pericardial, Pulmonary, Congenital Heart Disease
G. Aortic Disease, Peripheral Vascular Disease, Stroke
H. Interventional Cardiology and Cardiovascular Surgery
I. Hypertension
J. Preventive Cardiology
K. Cardiovascular Disease In Special Populations
L. Cardiovascular Pharmacology
M. Cardiovascular Nursing
N. E-Cardiology / Digital Health, Public Health, Health Economics, Research Methodology
O. Basic Science
P. Other
0 Themes
01. History of Cardiology
02. Clinical Skills
03. Imaging
04. Arrhythmias, General
05. Atrial Fibrillation
06. Supraventricular Tachycardia (non-AF)
07. Syncope and Bradycardia
08. Ventricular Arrhythmias and Sudden Cardiac Death (SCD)
09. Device Therapy
10. Chronic Heart Failure
11. Acute Heart Failure
12. Coronary Artery Disease (Chronic)
13. Acute Coronary Syndromes
14. Acute Cardiac Care
15. Valvular Heart Disease
16. Infective Endocarditis
17. Myocardial Disease
18. Pericardial Disease
19. Tumors of the Heart
20. Congenital Heart Disease and Pediatric Cardiology
21. Pulmonary Circulation, Pulmonary Embolism, Right Heart Failure
22. Aortic Disease
23. Peripheral Vascular and Cerebrovascular Disease
24. Stroke
25. Interventional Cardiology
26. Cardiovascular Surgery
27. Hypertension
28. Risk Factors and Prevention
29. Rehabilitation and Sports Cardiology
30. Cardiovascular Disease in Special Populations
31. Pharmacology and Pharmacotherapy
32. Cardiovascular Nursing
33. e-Cardiology / Digital Health
34. Public Health and Health Economics
35. Research Methodology
36. Basic Science
37. Miscellanea
0 Resources
Abstract
Slides
Vídeo
Report
CLEAR FILTERS
Uncovering Predictors of Adverse Outcomes in HFrEF After Acute Myocardial Infarction
Session:
SESSÃO DE POSTERS 08 - DOENÇAS CARDIOVASCULARES - PROGNÓSTICO NO SCA
Speaker:
Daniel Inácio Cazeiro
Congress:
CPC 2025
Topic:
D. Heart Failure
Theme:
10. Chronic Heart Failure
Subtheme:
10.2 Chronic Heart Failure – Epidemiology, Prognosis, Outcome
Session Type:
Cartazes
FP Number:
---
Authors:
Daniel Inácio Cazeiro; Catarina Gregório; Diogo Ferreira; Fátima Salazar; Ana Francês; Rafael Santos; Joana Rigueira; Doroteia Silva; Nuno Lousada; Fausto J. Pinto; Dulce Brito; João Agostinho
Abstract
<p style="text-align:justify"><span style="font-size:11pt"><span style="font-family:Arial,sans-serif"><span style="color:#000000"><strong>Introduction:</strong></span></span></span><br /> <span style="font-size:11pt"><span style="font-family:Arial,sans-serif"><span style="color:#000000">Ischemic heart disease is the leading cause of heart failure (HF) with reduced left ventricle ejection fraction (LVEF). Acute myocardial infarction often serves as the precipitating event that leads to LVEF reduction and, in some cases, to HF. However, while some patients fully recover their LVEF and avoid developing HF with revascularization and optimized medical therapy, others remain with reduced LVEF and end up developing HF symptoms. The aim of this study is to define predictors of cardiovascular (CV) death or HF hospitalization (HFH) in this population.</span></span></span></p> <p style="text-align:justify"><span style="font-size:11pt"><span style="font-family:Arial,sans-serif"><span style="color:#000000"><strong>Methods:</strong></span></span></span><br /> <span style="font-size:11pt"><span style="font-family:Arial,sans-serif"><span style="color:#000000">This prospective, single-center study included post-myocardial infarction patients with LVEF <50% at discharge, who started being followed at a HF-specialized outpatient clinic since 2020. The primary outcome was a composite of CV death or HFH at 3 years. Logistic regression, receiver operating characteristic curve and Kaplan-Meier survival analysis were performed to identify predictors of poor outcomes.</span></span></span></p> <p style="text-align:justify"><span style="font-size:11pt"><span style="font-family:Arial,sans-serif"><span style="color:#000000"><strong>Results:</strong></span></span></span><br /> <span style="font-size:11pt"><span style="font-family:Arial,sans-serif"><span style="color:#000000">The study included 92 patients (22.8% female, mean age: 66.5 ± 11.5 years) with a mean follow-up of 2.5 years. Baseline mean LVEF was 31%, and median NT-proBNP was 2354 pg/mL; 46.7% were discharged without diuretic therapy. After one year of optimized medical therapy, the mean LVEF improved to 41%, 63% of patients no longer required furosemide, and 51%, were in NYHA class I.</span></span></span><br /> <span style="font-size:11pt"><span style="font-family:Arial,sans-serif"><span style="color:#000000">At three years, baseline LVEF <33% was associated with an increased risk of the composite outcome (HR: 5.7; 95% CI: 1.3–30.9; p=0.04). A left atrial indexed volume >41 mL/m² was also strongly associated with worse outcomes (HR: 8.5; 95% CI: 1.8–39.6; p=0.006). Additional predictors of poor prognosis included a delay of >50 days to the first post-discharge appointment (HR: 4.8; 95% CI: 1.1–17.4; p=0.05) and diuretic therapy at discharge (HR: 5.6; 95% CI: 1.2–26.7; p=0.03). In contrast, baseline creatinine, LDL cholesterol, NT-proBNP levels, and foundational HF therapy doses were not statistically associated with outcomes.</span></span></span></p> <p><span style="font-size:11pt"><span style="font-family:Arial,sans-serif"><span style="color:#000000"><strong>Conclusion:</strong></span></span></span><br /> <span style="font-size:11pt"><span style="font-family:Arial,sans-serif"><span style="color:#000000">In this cohort, baseline LVEF <33%, left atrial indexed volume >41 mL/m², delayed follow-up (>50 days), and diuretic need at discharge were significant predictors of cardiovascular death and HF hospitalization. These findings highlight the importance of early follow-up and tailored guideline directed medical therapy for patients with any of those characteristics at discharge. </span></span></span></p>
Slides
Our mission: To reduce the burden of cardiovascular disease
Visit our site