SPC365

Fibrinogen is correlated to increased arterial stiffness on hypertensive individuals

Session: SESSÃO DE COMUNICAÇÕES ORAIS 01– DOS LÍPIDOS AOS GENES - FATORES DE RISCO E BIOLOGIA MOLECULAR NA ATEROSCLEROSE E SAÚDE CARDIOVASCULAR
Speaker: Cláudia C. Sousa

Congress: CPC 2025
Topic: I. Hypertension
Theme: 27. Hypertension
Subtheme: 27.7 Hypertension - Other
Session Type: Comunicações Orais
FP Number: ---
Authors: Cláudia C. Sousa; Ana Célia Sousa; Patrícia Nunes; João Gouveia; Mónica Jardim; Sara Gomes; Sofia Borges; Maria João Oliveira; Mariana Rodrigues; Eva Henriques; Maria Isabel Mendonça; Roberto Palma Dos Reis

<p style="text-align:justify"><span style="font-size:11pt"><span style="font-family:Calibri,&quot;sans-serif&quot;"><strong><span style="font-size:12.0pt">Introduction:</span></strong></span></span></p>

<p style="text-align:justify"><span style="font-size:11pt"><span style="font-family:Calibri,&quot;sans-serif&quot;"><span style="font-size:12.0pt">Arterial hypertension is the main risk factor for the development of arterial stiffness. Arterial elastic properties are important for cardiovascular function and predictors of cardiovascular risk. Fibrinogen is an inflammatory marker that stimulates endothelial dysfunction, leading to an increase in arterial stiffness. However, these mechanisms of subclinical inflammation, triggered at the level of the vascular wall, remain unknown</span><strong><span style="font-size:12.0pt">. </span></strong></span></span></p>

<p style="text-align:justify"><span style="font-size:11pt"><span style="font-family:Calibri,&quot;sans-serif&quot;"><strong><span style="font-size:12.0pt">Objectivo:</span></strong></span></span></p>

<p style="text-align:justify"><span style="font-size:11pt"><span style="font-family:Calibri,&quot;sans-serif&quot;"><span style="font-size:12.0pt">Evaluate whether serum fibrinogen is associated with increased arterial stiffness in a Portuguese hypertensive population.</span></span></span></p>

<p style="text-align:justify"><span style="font-size:11pt"><span style="font-family:Calibri,&quot;sans-serif&quot;"><strong><span style="font-size:12.0pt">Methods:</span></strong> </span></span></p>

<p style="text-align:justify"><span style="font-size:11pt"><span style="font-family:Calibri,&quot;sans-serif&quot;"><span style="font-size:12.0pt">A study was performed in a Portuguese population of 860 hypertensive individuals (aged 52.0 </span><span style="font-size:12.0pt">&plusmn;</span><span style="font-size:12.0pt"> 8.0 years; 53.3% male). Pulse wave velocity (PWV) was determined using the Complior method, which is an arterial distensibility index. A case-control study was performed depending on whether they had high PWV (</span><span style="font-size:12.0pt">&ge;</span><span style="font-size:12.0pt">10 m/s) or not (&lt;10m/s). Serum fibrinogen levels were determined in both groups. Subsequently, a multivariate analysis was performed with other conventional risk factors for cardiovascular disease, namely: diabetes, dyslipidemia, alcohol consumption and smoking to estimate which variables were significantly and independently associated with increased PWV.</span></span></span></p>

<p style="text-align:justify"><span style="font-size:11pt"><span style="font-family:Calibri,&quot;sans-serif&quot;"><strong><span style="font-size:12.0pt">Results:</span></strong> </span></span></p>

<p style="text-align:justify"><span style="font-size:11pt"><span style="font-family:Calibri,&quot;sans-serif&quot;"><span style="font-size:12.0pt">Cases group (PWV</span><span style="font-size:12.0pt">&ge;</span><span style="font-size:12.0pt">10 m/s) consisted of 130 individuals and the control group (PWV ?10 m/s) consisted of 730 individuals. In a hypertensive population, individuals with higher PWV have increased serum fibrinogen levels than those with lower PWV (402.77 &plusmn; 93.10 mg/dL versus 380.28 &plusmn; 80.75 mg/dL; p=0.004).</span><span style="font-size:12.0pt"> A positive Pearson correlation was found between fibrinogen and PWV (p&lt;0.0001). </span><span style="font-size:12.0pt">After logistic regression analysis, the risk factors that remained in the equation as significantly and independently associated with PWV increase were: </span><span style="font-size:12.0pt">diabetes OR=2.138 (95%CI 1.400-3.264; p&lt;0.0001), alcohol abuse OR=1.511 (95%CI 1.027-2.224; p=0.036) and fibrinogen OR=1.003 (95% CI 1.001-1.005; p=0.006).</span> </span></span></p>

<p style="text-align:justify"><span style="font-size:11pt"><span style="font-family:Calibri,&quot;sans-serif&quot;"><strong><span style="font-size:12.0pt">Conclusions:</span></strong> </span></span></p>

<p style="text-align:justify"><span style="font-size:11pt"><span style="font-family:Calibri,&quot;sans-serif&quot;"><span style="font-size:12.0pt">The findings demonstrate a significant and independent association between serum fibrinogen levels and increased arterial stiffness in patients with hypertension. This underscores fibrinogen&#39;s crucial role as a marker of arterial wall injury and reinforces its involvement in the pathophysiology of arterial stiffness. To mitigate cardiovascular risks, it is essential to implement control measures in hypertensive individuals aimed at reducing both arterial stiffness and fibrinogen levels.</span></span></span></p>