SPC365

Long-term outcomes of ventricular tachycardia ablation in patients presenting with electrical storm

Session: SESSÃO DE COMUNICAÇÕES ORAIS 12 - AVANÇOS EM ABLAÇÃO: TÉCNICAS, FERRAMENTAS E RESULTADOS
Speaker: Joana Certo Pereira

Congress: CPC 2025
Topic: C. Arrhythmias and Device Therapy
Theme: 08. Ventricular Arrhythmias and Sudden Cardiac Death (SCD)
Subtheme: 08.4 Ventricular Arrhythmias and SCD - Treatment
Session Type: Comunicações Orais
FP Number: ---
Authors: Joana Certo Pereira; Rita Barbosa Sousa; Daniel A. Gomes; Daniel Matos; Gustavo Rodrigues; João Carmo; Pedro Galvão Santos; Pedro Carmo; Francisco Moscoso Costa; Diogo Cavaco; Francisco Belo Morgado; Pedro Adragão

<p style="text-align:justify"><span style="font-size:11pt"><span style="font-family:Calibri,sans-serif"><strong>Background:</strong></span></span></p>

<p style="text-align:justify"><span style="font-size:11pt"><span style="font-family:Calibri,sans-serif">Catheter ablation (CA) is an established therapy for drug-resistant ventricular tachycardia (VT). Although previous reports suggest higher recurrence and mortality rates in patients presenting with electrical storm (ES), data on mid- and long-term outcomes remain scarce. We aimed to evaluate the clinical characteristics and long-term outcomes of patients presenting with ES undergoing VT ablation.</span></span></p>

<p style="text-align:justify"><span style="font-size:11pt"><span style="font-family:Calibri,sans-serif"><strong>Methods:</strong></span></span></p>

<p style="text-align:justify"><span style="font-size:11pt"><span style="font-family:Calibri,sans-serif">Single-centre registry of consecutive patients undergoing scar-related VT ablation from 2010 to 2024. ES was defined as &ge;3 episodes of sustained VT or ventricular fibrillation in 24h. Clinical and procedural characteristics were assessed and compared between groups. Primary outcomes were VT-free survival and all-cause mortality. Safety outcome was a composite of tamponade, hemodynamic decompensation, acute heart failure, stroke, and procedure-related mortality.</span></span></p>

<p style="text-align:justify"><span style="font-size:11pt"><span style="font-family:Calibri,sans-serif"><strong>Results:</strong></span></span></p>

<p style="text-align:justify"><span style="font-size:11pt"><span style="font-family:Calibri,sans-serif">A total of 298 patients (aged 65&plusmn;13years, 91% male, mean left ventricular ejection fraction [LVEF] 34&plusmn;11%, 67% with ischemic cardiomyopathy, 20% redo procedures) were included. ES at presentation was observed in 32% (N=96). Patients with ES had worse functional status (NYHA III-IV: 38.5% vs. 17.8%, P&lt;0.001), although there were no differences regarding age, sex, aetiology, and LVEF.</span></span></p>

<p style="text-align:justify"><span style="font-size:11pt"><span style="font-family:Calibri,sans-serif">Procedure and fluoroscopy duration were similar (165 vs. 154 min, P=0.20; and 15 vs. 13 min, P=0.20; respectively), and acute non-inducibility of VT was achieved in 81.4% (P=0.772). Overall, the VT ablation approach was endocardial in 83.6% (n= 249), epicardial in 7.3% (n=22), and combined&nbsp;in 9.1% (n=27). Major complications were rare, including 2 cases of tamponade, 2 right ventricular punctures, 1 cases of acute heart failure with hemodynamic decompensation, and 2 procedure-related death. The complications rate was higher in the ES group (5.2% vs. 1.0%, P=0.025).&nbsp; </span></span></p>

<p style="text-align:justify"><span style="font-size:11pt"><span style="font-family:Calibri,sans-serif">During a median follow-up of 3.4 (IQR 1.4-7.2) years, 127 patients (42.6%) suffered a VT relapse and 104 (34.9%) died. Compared to others, patients presenting with ES had higher rates of VT recurrence (53.3%/year vs. 23.6%/ year, log rank P=0.014) and death (16.4%/ year vs. 9.7%/ year, log rank P=0.007). &ndash; Figure 1. ES remained independently associated with VT recurrence, even after adjusting for six clinical confounders (aHR 1.50 [95% CI 1.02-2.19], P=0.039). Non-ischaemic aetiology (aHR 1.79 [95% CI 1.21-2.66], P=0.004), atrial fibrillation (aHR 1.71 [95% CI 1.17-2.52], P=0.006) and chronic kidney disease (aHR 1.59 [95% CI 1.08-2.35], P=0.019) were the other predictors of relapse.</span></span></p>

<p style="text-align:justify"><span style="font-size:11pt"><span style="font-family:Calibri,sans-serif"><strong>Conclusions:</strong></span></span></p>

<p style="text-align:justify"><span style="font-size:11pt"><span style="font-family:Calibri,sans-serif">Patients presenting with ES undergoing VT ablation had higher rates of VT recurrence, mortality, and major complications compared to those without ES, even achieving similar acute procedural success. ES was an independent predictor of poorer long-term outcomes, highlighting the need for targeted strategies to improve prognosis in this high-risk population.</span></span></p>